An acute dose of 2,000mg/kg Deer Velvet Antler to rats (human equivalent dose of 320mg/kg) has failed to show toxic signs over 14 subsequent days of observation, and a 90 day trial with daily dosing of 1,000mg/kg did not show any significant toxicological symptoms of haemotological signs; a decrease in liver weight was noted in males, but under histological examination it appeared to be benign.[38] Another rat toxicological study using 10% of the diet as Deer Velvet Antler during gestation and after birth noted that there were no apparent teratogenic effects on the rat pups and that serum AST (indicative of liver damage) was actually decreased 50% relative to control with no effect on γ-GT (another liver enzyme).[30]
Companies attributing health claims from using dietary supplements of velvet antler have received warning letters from the US Food and Drug Administration (FDA) concerning the sale of encapsulated powders connected to their marketing claims.[12] The claims were in violation of the United States Food, Drug and Cosmetic Act [21 USC/321 (g)(1)][36] because they "establish the product as a drug intended for use in the cure, mitigation, treatment, or prevention of disease" when velvet antler has no such scientific evaluation. Additionally stated by the FDA, velvet antler was "not generally recognized as safe and effective for the referenced conditions" and therefore must be treated as a "new drug" under Section 21(p) of the Act. New drugs may not be legally marketed in the United States without prior approval of the FDA.[12][14][15][16][17] As of 2018, it is legal to sell velvet antler powder, extract or spray in the U.S. as a dietary supplement as long as no disease treatment claims are made and the label bears the FDA disclaimer: "This product has not been evaluated by the FDA. It is not intended to diagnose, treat, cure or prevent any disease."
Andouiller de Cerf, Antler Velvet, Bois de Cerf, Bois de Cerf Rouge, Bois de Chevreuil, Bois de Velours, Bois de Wapiti, Cervus elaphus, Cervus nippon, Cornu Cervi Parvum, Deer Antler, Deer Antler Velvet, Elk Antler, Elk Antler Velvet, Horns of Gold, Lu Rong, Nokyong, Rokujo, Terciopelo de Cuerno de Venado, Velours de Cerf, Velvet Antler, Velvet Dear Antler, Velvet of Young Deer Horn.


A study by Chen found that deer antler velvet inhibits monoamine oxidase activity in the liver and brain tissues of aged mice. Monoamine-oxidase inhibitors prevent breakdown of monoamine neurotransmitters such as norepinephrine and serotonin. Antler apparently allows these vital neurotransmitters to be available longer to the brain structure, enhancing mood.

Using deer antler velvet benefits sexual functions and libido by helping to increase gonadotropin hormones which include luteinizing hormone (LH) and follicle-stimulating hormone (FSH). Luteinizing hormone (LH) and follicle-stimulating hormone are hormones that stimulate the sex glands. The stimulation of the sex glands is pivotal for sexual reproduction. Without the presence of the gonadotropin hormones, the sexual organs will fail at their purpose and the individual will be considered infertile. As the deer antler velvet promotes an increase in LH, the LH causes the testes to produce more testosterone.


In an ovalbumin sensitized mouse model, 4 weeks of Velvet Antler at 2.5-10mg total (weight of mice not given, assuming 20g this equals 125-500mg/kg or 10-40mg/kg for humans) was able to reduce total Immunoglobulin E (IgE) and Ovalbumin-specific IgE at 14, 21, and 28 days.[21] When challenged with methacholine and subsequently having their airway power measured, it appeared that Velvet Antler exert anti-asthmatic effects in regards to allergies.[21] 


In an ovalbumin sensitized mouse model, 4 weeks of Velvet Antler at 2.5-10mg total (weight of mice not given, assuming 20g this equals 125-500mg/kg or 10-40mg/kg for humans) was able to reduce total Immunoglobulin E (IgE) and Ovalbumin-specific IgE at 14, 21, and 28 days.[21] When challenged with methacholine and subsequently having their airway power measured, it appeared that Velvet Antler exert anti-asthmatic effects in regards to allergies.[21] 
The message was from Neema Yazdani. Some of you might recognize Neema’s name from my most recent book, The Men’s Health Big Book: Getting Abs. Neema was a test subject that epitomized the great results you could receive with the program. As a guy that had tried just about everything during the last 12 years, Neema dropped body fat and added muscle with a simpler approach included in the book.
Muscle Builder* - Some "experts" make bold claims that it builds muscle. They compare it to synthetic anabolics that give many athletes who dope an advantage over the competition. This is folly claim that has no backing from direct research or research into other associated fields that would be relevant to deer antler spray. Only one thing will build muscle: proper resistance training. Make the right choice and get to work.*
I was first introduced to and started using IGF-1 Plus™ in July of 1999. I made it part of my daily regiment originally to increase my stamina and build my muscles while burning body fat at the same time (which I was informed this would help me accomplish). I am 35 years old and exercise for about an hour or so at a time, 3 to 4 times a week. It is now the end of February 2000 and I’m extremely impressed at the results! People have commented on my appearance and I have been reaching new heights in the gym that I though were only obtainable by using drugs like steroids (which I never considered taking due to the unwanted side effects). However IGF-1 has not only increased my strength and endurance, but has given me much more in ways that I had not anticipated! For instance, the person who shared this with me had no idea that I have arthritis. I would wake up in the morning and my joints would ache severely (especially my wrists and elbows) until eleven o’clock or noon. Now, although it took me a few weeks to start really noticing my improvements in the gym, it didn’t take but 3 -4 days for me to take notice of the fact that my morning arthritis pains were completely gone. The only time the pain has come back is when I ran out of the spray and couldn’t get a hold of any for a couple of weeks because I was out of town vacationing in Florida. Now I try to have at least a couple extra bottles on hand! Also, my hair stylist of 17 years had noticed that I had lost a significant amount of gray on my head and asked if I was coloring my hair. I’ll make sure I never run out of this amazing formula again!!!
A systemic review on human interventions[25] makes note of a study conducted on patients of osteoarthritis (Edelman et al. 2000; cannot be located online) which found improvements in joint pain symptoms relative to baseline in the Velvet Antler group and not placebo, although a lack of information on blinding and randomization precludes results that can be drawn from this study.
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