Deer antler velvet is rich in insulin-like growth factor 1 (IGF-1) which is a growth hormone produced naturally in the liver as a response to human growth hormone (HGH) stimulation. This is a key factor in how deer antler velvet can help to promote muscle growth. IGF-1 works on the body by promoting the growth of healthy, lean skeletal muscles. This growth of healthy muscle mass can be influenced by IGF-1's tendency to increase muscle protein and muscle DNA content. There is evidence to suggest that IGF-1 acts on muscle tissue by promoting protein synthesis and the proliferation of satellite cells, both of which result in skeletal muscle growth due to the enlargement of the muscle cells.
Data is limited. Two studies (n=40 and 168) investigating the efficacy of elk velvet antler supplementation on rheumatoid arthritis found no effect, while a study conducted in people with osteoarthritis (n=53) reported symptomatic relief among participants. The small sample sizes may result in the trials being underpowered to detect effects.25, 28, 29
IGF-1 is currently on the World Anti-Doping Agency’s prohibited list due to how it gives athletes an unfair advantage in terms of building strength and muscle mass. (7) However, it’s still legal to use supplements that may provide IGF-1 or similar effects. Most of the studies that show positive results from using deer antler supplements have used high doses. And some have tested the product on animals (mice or rats) rather than humans.
Deer antler velvet can play a pivotal role in helping to not only relieve the symptoms of diseases that affect joints, such as osteoarthritis, they can possibly eliminate them entirely. The way it may do this is through the introduction of chondroitin sulfate and glucosamine sulfate into the body. Both of these compounds are abundant in deer antler velvet.