A systemic review on human interventions[25] makes note of a study conducted on patients of osteoarthritis (Edelman et al. 2000; cannot be located online) which found improvements in joint pain symptoms relative to baseline in the Velvet Antler group and not placebo, although a lack of information on blinding and randomization precludes results that can be drawn from this study.
Russian and Japanese researchers have conducted experiments using deer antler extract and found that it appears to lower blood pressure in both human subjects and laboratory animals. A series of clinical case studies (Albov, 1969) were conducted in which the effects of Pantocrin on cardiac patients were assessed. In one test involving 32 subjects with high blood pressure caused by cardiac disease, early onset menopause or obesity, blood pressure was lowered in 81% of patients. In another study involving 13 patients with hypotension caused by disorders of heart muscle activity, blood pressure was lowered for 84% of patients.
Immortal Antler Velvet Gold is the Mercedes of antler velvet extracts. It is the only all-natural 43:1 extract that contains a powerful blend of growth factors in a naturally occurring matrix. These naturally occurring growth factors are involved in every cellular function in the human body, from metabolism to immune response. Immortal Antler Velvet Gold is the only all-natural proprietary matrix to deliver up to 100 mcg’s of IGF-1 per bottle, in addition to the full growth factor matrix. Delivering a full range of growth factors at an alarming 43:1 ratio means there is no stronger formula on the market today. This ratio means it requires 43 lbs of velvet antler tips to create 1 lb of this complete formula. It is extracted in organic grape alcohol and bottled in miron violet glass for maximum absorption and effectiveness.

First, the facts: Deer antler has been a popular element of Eastern medicine for centuries. And—like red meat, eggs, or milk—deer antler contains small amounts of insulin-like growth factor 1, or IGF-1, explains Oliver Catlin, president of the Banned Substances Control Group (BSCG), which tests dietary supplements for illegal performance enhancers.

When antlers fall off, they leave wounds that heal quickly, without forming a scar. Researchers have found that velvet antler contains substances that encourage healing, and could be of use to humans. Of particular interest are 3 hormones known to promote growth of skin tissue: insulin-like growth factor (IGF-1), epidermal growth factor (EGF) and transforming growth factor-β1 (TGF-β1). In a recent study, an ointment made from velvet antler, containing these compounds, enhanced healing when applied to the skin of rats. IGF-1 was a hot topic in the media in the winter of 2013 when a football player, Ray Lewis, was accused of using a banned spray containing IGF-1.
After about 55-60 days of growth the velvet antler is removed painlessly from the deer in less than 60 seconds so that it may be done as humanely as possible. These deer are not harmed and experience no pain in the removal of their velvet antlers for our consumption. The antler is then scraped of its fuzzy velvet and then cleaned before it is sanitized and pasteurized for safety, and then inspected for quality grading.
As this supplement is derived from 'deer', the two most commonly used species of deer in mainland China include the Sika deer Cervus nippon Temminck and Red Deer Cervus elaphus Linnaeus; these species may be relevant.[1] 'Farming' of deers for antlers includes raising deer and sawing off the antlers under analgesia,[2][3] the annual yeild appears to be 120-150 tonnes and deer are not usually killed as antlers are capable of full regeneration.[3]
To be clear, some doctors and researchers have stated that they feel deer antler spray is unlikely to cause any significant benefits. This is because it only provides very small amounts of IGF-1, some of which may not even be fully absorbed. However, studies do show that higher doses, or using very high-quality supplements, may contribute to some improvements in performance, body composition, etc. IGF-1 itself has been studied extensively. It can certainly change the way the body looks and operates. Whether or not the role of IGF-1 in the body will translate into any real benefits when obtained from deer antler products will depend on the specific person and dosage used.
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In a randomized, placebo controlled test in 2004, researchers at the University of Alberta, Canada, placed 18 males from the Edmonton Police Force into a 9 week strength training program. The results showed that deer antler velvet increased the strength and endurance of the subjects relative to the control group. The researchers found that use of deer antler velvet significantly increased blood plasma testosterone levels. 
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