One study[14] (duplicated in Medline[15]) that used a water extract of Velvet Antler at 50-200mg/kg failed to inhibit the pain killing effect of Morphine yet reduced the rate at which rats became tolerant to Morphine over the course of 6 days when taken an hour prior to Morphine each day.[14] Rats who were given Velvet Antler prior to Morphine also experienced 26.6-36.6% less withdrawal (dose-dependent) and reduced reverse tolerance and dopamine receptor supersensitivity relative to morphine control.[14]
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The harvesting of deer antler velvet can be a painful process, as the velvet tissue contains an abundance of nerves and bleeds profusely if cut or removed. Dr. Low Dog says she has no problem with harvesting velvet from deer killed for food, but is concerned that shortcuts will be taken should demand for the supplements continue to grow. She notes that the United Kingdom has banned the removal of deer antler velvet under its welfare-of-livestock regulations, unless the antlers have been damaged or most of the velvet has been shed.
Data is limited. Two studies (n=40 and 168) investigating the efficacy of elk velvet antler supplementation on rheumatoid arthritis found no effect, while a study conducted in people with osteoarthritis (n=53) reported symptomatic relief among participants. The small sample sizes may result in the trials being underpowered to detect effects.25, 28, 29
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L-Arginine: An amino acid usually found in red meats that is important for the body’s ability to manufacture proteins. L-Arginine has been used to treat conditions like high blood pressure, congestive heart failure, blocked arteries, and erectile dysfunction. L-Arginine is safe for most people, however it should not be taken by women that are pregnant or breastfeeding.
Reports claim deer antler helped Ray Lewis overcome his recent triceps tear, and Vijay Singh has admitted to using a spray supplement. University of Alabama football players also allegedly used deer antler sprays leading up to the 2013 BCS National Title Game. Whether or not those reports are true, one thing is certain: There’s not much proof that deer antler is a performance enhancer or a miraculous healer.

It is difficult to analyze the quality of Deer Antler Velvet Spray’s ingredients due to their largely untested nature. Deer velvet contains glucosamine and chondroitin, two key chemicals in the body’s joint health processes that our panel of experts highly recommends. It may also increase estrogen production in the body, which can be both good and bad. In some that may be helpful for correcting existing hormonal imbalances, for others it may create them.
The FDA considers deer antler spray (or deer antler velvet) to be a dietary supplement. This means it doesn’t need to be extensively studied and regulated like medications. For this reason, it can be hard to tell what the actual concentration of active ingredients or IGF-1 is in various supplements. Plus products can differ quite a bit from one brand to another in terms of their purity and effectiveness.

When antlers fall off, they leave wounds that heal quickly, without forming a scar. Researchers have found that velvet antler contains substances that encourage healing, and could be of use to humans. Of particular interest are 3 hormones known to promote growth of skin tissue: insulin-like growth factor (IGF-1), epidermal growth factor (EGF) and transforming growth factor-β1 (TGF-β1). In a recent study, an ointment made from velvet antler, containing these compounds, enhanced healing when applied to the skin of rats. IGF-1 was a hot topic in the media in the winter of 2013 when a football player, Ray Lewis, was accused of using a banned spray containing IGF-1.
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