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In 168 persons with stable Rheumatoid Arthritis but present pain (25-100mm on the VAS rating scale) given either 1g of Velvet Antler from Elk or placebo for 6 months noted that there were no significant differences between placebo and Velvet Antler in regards to pain.[23] Another study by the same research group using a smaller sample (n=40) and graded doses of 430mg, 860mg, and 1290mg daily noted that there was a dose-dependent trend towards reduced pain symptoms but this was not statistically significant.[24]
Osteoarthritis is caused by the loss of cartilage in bone joints. In normal joints, cartilage serves as a buffer between bones. Usually the body replenishes cartilage as it wears away, but when osteoarthritis occurs, cartilage deteriorates faster than the body can replace it. Eventually, the bones begin to rub together, causing pain, swelling and loss of joint mobility. Most treatments for osteoarthritis attempt to reduce pain and maintain joint function, but these treatments do little to restore joint health.

When antlers fall off, they leave wounds that heal quickly, without forming a scar. Researchers have found that velvet antler contains substances that encourage healing, and could be of use to humans. Of particular interest are 3 hormones known to promote growth of skin tissue: insulin-like growth factor (IGF-1), epidermal growth factor (EGF) and transforming growth factor-β1 (TGF-β1). In a recent study, an ointment made from velvet antler, containing these compounds, enhanced healing when applied to the skin of rats. IGF-1 was a hot topic in the media in the winter of 2013 when a football player, Ray Lewis, was accused of using a banned spray containing IGF-1.

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Elk velvet antlers have been shown to contain chondroitin sulfate. This has a growth-promoting effect on cells throughout the body, which helps with recovery. This includes cells in the gut. It is believed that cartilage proteoglycans regulate water retention and differentiation and proliferation of chondrocytes inside cartilage tissue. Four types of collagen (I, II, III, and X) have also been identified in deer antlers. The collagen may provide benefits including rebuilding damaged parts of the GI tract, skin and joints. This might be beneficial for preventing or helping to treat leaky gut syndrome, which contributes to widespread symptoms.
A systemic review on human interventions[25] makes note of a study conducted on patients of osteoarthritis (Edelman et al. 2000; cannot be located online) which found improvements in joint pain symptoms relative to baseline in the Velvet Antler group and not placebo, although a lack of information on blinding and randomization precludes results that can be drawn from this study.
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