One study[14] (duplicated in Medline[15]) that used a water extract of Velvet Antler at 50-200mg/kg failed to inhibit the pain killing effect of Morphine yet reduced the rate at which rats became tolerant to Morphine over the course of 6 days when taken an hour prior to Morphine each day.[14] Rats who were given Velvet Antler prior to Morphine also experienced 26.6-36.6% less withdrawal (dose-dependent) and reduced reverse tolerance and dopamine receptor supersensitivity relative to morphine control.[14]
Deer antler velvet is the tissue that covers the bone and cartilage that develop into deer (and elk) antlers. It has been harvested for centuries and used traditionally to increase strength, boost the immune system, and counter the effects of stress. Now it’s promoted to improve athletic performance; raise testosterone levels to increase sex drive, fertility and erectile function in men; as well as to reduce the signs of aging and treat problems ranging from high cholesterol, high blood pressure, asthma and osteoporosis to migraine headaches, indigestion, and many more.
It is recently gaining popularity in the USA as seen with the deer antler spray controversy a couple years ago concerning several professional athletes. Oh yeah, I heard its a performance enhancer. They were consuming it for its natural growth factors, extracted via cold water, which are known to promote growth and regeneration capacities. Natural? Yes, and healthy. Where does this stuff come from?
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A Russian study indicated that the amino acids, polypeptides and other compounds found in antler increased the survival rate of mice with cancerous tumors as much as 40 percent. In addition, a study conducted by the East-West Research Institute in Korea found that deer antler velvet appears to increase neutrophil levels in mice, which boost the body’s ability to fight injuries and disease. The mice with tumors lost less weight and suffered lower levels of kidney damage than those treated with drugs.
New Zealand research reports that although the mechanism is unknown, deer antler velvet shows strong anti-inflammatory effects. Recent clinical tests suggest oral ingestion of glycosaminoglycan-peptide complex, or components such as chondroitin sulfate and glucosamine sulfate — both found in deer antler velvet — may help stimulate cartilage repair.
Published research has shown that IGF-1 can produce similar results to growth hormone. The catch? If you do the math from the study, a 150-pound man (that’s a pretty small guy, so a bigger man would need more) would have to take more than 25 million nanograms just to experience the growth hormone-like effects of more muscle, less fat, and faster recovery.
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Euricoma Longfolia: A shrub found in Southeast Asia that is said by some native cultures to enhance male virility. It has been used unofficially to treat fever, high blood pressure, bone pain, and syphilis, and the limited clinical data about euricoma longfolia that exists suggests it may possibly increase testosterone levels. There is no data about the long-term effects of euricoma longfolia consumption.

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Currently, one study that induced a fracture unto a rat bone and injected 20mg/kg of Velvet Antler polypeptides into the area every other day for 7 weeks noted that fracture healing rate was dose-dependently increased at weeks 4-7 relative to control and that the bone loading weight was increased following rehabilitation with 10mg/kg (60.7%) and 20mg/kg (93% more than control) after 7 weeks.[29] An in vitro study suggested that this was due to a concentration-dependent mitogenic activity on osteoblastic precursors and chondrocytes.[29]

In a double blind study (Edelman, 2000), 54 patients with arthritis in the knee were given deer antler velvet or a placebo and assessed at 1, 3 and 6 months. Patients treated with deer antler velvet showed improvement in pain and physical global assessment at 3 and 6 months. No significant improvement was observed for the placebo group for any of the parameters examined.
In a randomized, placebo controlled test in 2004, researchers at the University of Alberta, Canada, placed 18 males from the Edmonton Police Force into a 9 week strength training program. The results showed that deer antler velvet increased the strength and endurance of the subjects relative to the control group. The researchers found that use of deer antler velvet significantly increased blood plasma testosterone levels. 
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