As men and women get older, they naturally start producing less Human Growth Hormone (HGH). So levels of IGF-1 also decline with age. The liver produces IGF-1 when HGH is released.  HGH is converted to IGF-1. Aside from someone’s age, IGF-1 levels will vary depending on a person’s sex (men generally have more), level of activity, their diet, genetics and lifestyle.
In Asia, velvet antler is dried and sold as slices, or as a powder which may be boiled in water, usually with other herbs and ingredients, and consumed as a medicinal soup.[6] In the traditional commercial trade of Korea and China, whole stick antler velvet is divided into three sections based upon their supposed properties. Although there is an absence of uniform standardization, these sections are known as the wax piece (uppers or tips), the blood piece (middles), and the bone piece (bottoms): the wax piece may be marketed as a growth tonic for children, the blood piece supposedly for joint and bone health, and the bone piece supposedly for calcium deficiency and geriatric needs.[2][5][9] Early commercial activity in Russia between the 1930s and 1980s led to the production of an alcohol extract from deer antler velvet marketed under the Russian drug trade name Pantocrin (also pantocrine or pantokrin).[10][11]
The truth? While research is limited, there’s nothing to suggest that deer antler velvet (or deer antler spray in the supplement form) actually does what it claims. In fact, there are two published studies (in real scientific journals, you can see them here and here) that suggest deer antler velvet does not (I repeat, does not) even elicit a hormonal response. What’s more, it also did not increase muscular strength or aerobic power.
One study[14] (duplicated in Medline[15]) that used a water extract of Velvet Antler at 50-200mg/kg failed to inhibit the pain killing effect of Morphine yet reduced the rate at which rats became tolerant to Morphine over the course of 6 days when taken an hour prior to Morphine each day.[14] Rats who were given Velvet Antler prior to Morphine also experienced 26.6-36.6% less withdrawal (dose-dependent) and reduced reverse tolerance and dopamine receptor supersensitivity relative to morphine control.[14]
The first question to ask, is why? Why are you considering this supplement? A supplement is not intended to fix a crappy diet or poor exercise program. A supplement is intended to be just that, a supplement to your existing good diet/good exercise program. And if you’re eating a well-rounded diet, then there’s really no need for supplementation at all.

One study published in the Journal of Ethnopharmacology found evidence that use of deer velvet antler may help strengthen joints and bones, reducing symptoms like joint pain associated with osteoarthritis. (10) After rats with osteoarthritic symptoms were given total velvet antler polypeptides from red deer (TVAPL) for 12 weeks, they showed signs of significant reversal in osteoporosis. The researchers found improvements in the rats’ bone weight coefficient (BWC), bone mineral density (BMD), and bone mineral content (BMC). They believe these effects were due to proliferation of cartilage and osteoblast-like cells, in addition to reductions in inflammation due to inhibition of interleukin-1 (IL-1).
I’ve been using it for about 4 months now with my diet and I’ve lost 80 lbs and gained a little muscle from it I can tell you my performance at work and in the gage lifting is awesome I feel like an animal I can go wok out for and 1 1/2 hrs and come in the house and sit down and squirting about 15 sprays of deer velvet extract under my tounge and in 30 minutes I’m ready to lift again it makes me recover really quick I’ve it!!!
Bottom line: Rogol says it’s “extremely unlikely” that deer antler in any form could offer athletes a boost. “Deer antlers do contain growth factors,” he explains. But it’s a huge leap of faith to talk about an extract doing anything beneficial for human beings, whether it’s slowing aging, developing muscle, or repairing tendons, he adds. Opinions like Rogol’s are one reason the FDA and anti-doping agencies haven’t yet taken steps to ban deer antler products that contain IGF-1.
Studies have found that deer antlers themselves contain a highly concentrated amount of essential trace minerals, fatty acids, amino acids and growth factors that can all support the immune system. This includes the gastrointestinal tract, where the majority of the immune system is found. Antlers contain minerals such as: calcium, phosphorus, magnesium, iron, potassium and sodium in addition to numerous minor components.
In herbal combinations, deer velvet is used to improve athletic performance; to improve eyesight and hearing; to reduce stress; and to treat arthritis, osteoporosis, “tired blood” (anemia), women’s reproductive disorders including premenstrual syndrome (PMS), ED, and skin conditions. Herbal combinations including deer velvet are also used to increase blood circulation to the brain and to delay or reduce signs of aging such as tissue, bone, and muscle degeneration, and declining mental skills.
Published research has shown that IGF-1 can produce similar results to growth hormone. The catch? If you do the math from the study, a 150-pound man (that’s a pretty small guy, so a bigger man would need more) would have to take more than 25 million nanograms just to experience the growth hormone-like effects of more muscle, less fat, and faster recovery.
A Russian study indicated that the amino acids, polypeptides and other compounds found in antler increased the survival rate of mice with cancerous tumors as much as 40 percent. In addition, a study conducted by the East-West Research Institute in Korea found that deer antler velvet appears to increase neutrophil levels in mice, which boost the body’s ability to fight injuries and disease. The mice with tumors lost less weight and suffered lower levels of kidney damage than those treated with drugs.
Increase your overall energy and motivation while getting the most of your rest and recovery. Adapting to stress assist will help us better regulate our immune, nervous and adrenal systems. Adapting to stress means hormonal health. Proper use could even benefit an overactive system that is depleted, therefore promoting greater health in those with adrenal fatigue. It does so by activating the glands which secrete hormones that boost recovery and regeneration.