A 2014 study published in Evidence Based Complimentary and Alternative Medicine tested whether or not deer antler extract would have an effect on fatigue in mice who were led to swim distances. The findings suggested that deer antler “might increase the muscle strength through the upregulation of genes responsible for muscle contraction and consequently exhibited the anti-fatigue effect in mice.” Deer antler seems to have a positive effect on genes involved in nine different signaling pathways that affect muscles, endurance and fatigue. These include GnRH signaling pathway and insulin signaling pathways, in addition to levels of troponins. (8) Deer antler may contribute to increases in muscle strength by increasing Tpm2 expression. This affects how muscles take up proteins and repair themselves. Other studies show some evidence that deer antler extract helps prevent muscle fatigue by activating the lactate dehydrogenase activities and reducing the levels of blood lactic acid and serum urea nitrogen.
In 1989, fitness expert John Abdo, who trained numerous Olympic and world class athletes, visited the Institute of Physical Culture in Moscow to investigate Russian training routines. At that time, Russian athletes underwent a dramatic increase in the success in weightlifting competitions. John met with former Soviet weight-lifting champion Victor Sheynkin and training expert Yuri Verhoshansky. John learned that their athletes had experienced considerable improvement in performance with deer antler velvet.  Dr Arkady Koltun, Chaiman of the Medical Committee for the Russian Bodybuilding Federation, and an expert on anabolic agents confirmed that deer antler velvet increases muscular strength and speeds recovery after exercise.
There is an increasing amount of scientific evidence supporting the benefits of deer antler velvet from decades of research carried out in Russia, Korea, China, Japan, Australia and New Zealand. This research has given credibility to deer antler velvet’s traditional usage and validated recommendations for its inclusion as an everyday health supplement. Almost 250 papers have been published since 1930 on the manufacture, composition and biochemical effect of deer antler velvet. Studies on deer antler velvet and the corresponding findings are described below.
I looked for a solution for years. Then I heard the buzz about Nutronics Labs IGF-1 Plus and its positive impact to ones health and its effectiveness on fat loss. I took the Nutronics IGF-1 Plus Maximum formula, and the search for a solution came to a halt. I was tipping the scale at an overweight 200lbs and with the assistance of IGF-1 Plus Max, I achieved a long life time goal of a lean 178lbs in 6wks.

I am considering getting this. I have late stage lymes disease that is in my brain and nervous system and it is ruining me. I cant get help anywhere. I have gained 50 lbs even though I eat healthy after working so hard to lose 248 lbs. Its ruined my brain. I am getting very concerned I am not going to get better and have tried everything. are you still taking it since it is a year later and what have you noticed? I am 47 yr old female. If you wouldnt mind emailing me back id appreciate it. powerhouseami at gmail
It is difficult to analyze the quality of Deer Antler Velvet Spray’s ingredients due to their largely untested nature. Deer velvet contains glucosamine and chondroitin, two key chemicals in the body’s joint health processes that our panel of experts highly recommends. It may also increase estrogen production in the body, which can be both good and bad. In some that may be helpful for correcting existing hormonal imbalances, for others it may create them.

Companies attributing health claims from using dietary supplements of velvet antler have received warning letters from the US Food and Drug Administration (FDA) concerning the sale of encapsulated powders connected to their marketing claims.[12] The claims were in violation of the United States Food, Drug and Cosmetic Act [21 USC/321 (g)(1)][36] because they "establish the product as a drug intended for use in the cure, mitigation, treatment, or prevention of disease" when velvet antler has no such scientific evaluation. Additionally stated by the FDA, velvet antler was "not generally recognized as safe and effective for the referenced conditions" and therefore must be treated as a "new drug" under Section 21(p) of the Act. New drugs may not be legally marketed in the United States without prior approval of the FDA.[12][14][15][16][17] As of 2018, it is legal to sell velvet antler powder, extract or spray in the U.S. as a dietary supplement as long as no disease treatment claims are made and the label bears the FDA disclaimer: "This product has not been evaluated by the FDA. It is not intended to diagnose, treat, cure or prevent any disease."
One of the leading companies in the world that manufacturers deer antler spray is called Nutronics Labs. According to information posted on their website, they have been making deer antler supplements for two decades. They state that their deer antler products range in concentration/strength from about 25,000ng (nanograms)–200,000ng of IGF-1. According to studies done by Nutronics Labs, deer antler powders appear to be less concentrated with IGF-1. They also may be poorly absorbed compared to deer antler extract.

An ethanolic extract has been noted to, following oral ingestion of 100mg/kg, suppress nitric oxide secretion from peritoneal macrophages while stimulating phagocytic activity secondary to calcium mobilization,[19] and has been noted to increase macrophage cell count in a concentration dependent manner up to 171.5% at 150mcg/mL with a water extract (and 132.4% for splenocytes).[18] This immunostimulation appears to be related to phosphatidylcholine molecules with saturated fatty acid acyl chains[20] and is thought to underlie an anti-infective effect in mice infected with Staphylococcus aureus when Velvet Antler is ingested at 500mg/kg.[18]
New Zealand research reports that although the mechanism is unknown, deer antler velvet shows strong anti-inflammatory effects. Recent clinical tests suggest oral ingestion of glycosaminoglycan-peptide complex, or components such as chondroitin sulfate and glucosamine sulfate — both found in deer antler velvet — may help stimulate cartilage repair.
One study published in the Journal of Ethnopharmacology found evidence that use of deer velvet antler may help strengthen joints and bones, reducing symptoms like joint pain associated with osteoarthritis. (10) After rats with osteoarthritic symptoms were given total velvet antler polypeptides from red deer (TVAPL) for 12 weeks, they showed signs of significant reversal in osteoporosis. The researchers found improvements in the rats’ bone weight coefficient (BWC), bone mineral density (BMD), and bone mineral content (BMC). They believe these effects were due to proliferation of cartilage and osteoblast-like cells, in addition to reductions in inflammation due to inhibition of interleukin-1 (IL-1).
Companies attributing health claims from using dietary supplements of velvet antler have received warning letters from the US Food and Drug Administration (FDA) concerning the sale of encapsulated powders connected to their marketing claims.[12] The claims were in violation of the United States Food, Drug and Cosmetic Act [21 USC/321 (g)(1)][36] because they "establish the product as a drug intended for use in the cure, mitigation, treatment, or prevention of disease" when velvet antler has no such scientific evaluation. Additionally stated by the FDA, velvet antler was "not generally recognized as safe and effective for the referenced conditions" and therefore must be treated as a "new drug" under Section 21(p) of the Act. New drugs may not be legally marketed in the United States without prior approval of the FDA.[12][14][15][16][17] As of 2018, it is legal to sell velvet antler powder, extract or spray in the U.S. as a dietary supplement as long as no disease treatment claims are made and the label bears the FDA disclaimer: "This product has not been evaluated by the FDA. It is not intended to diagnose, treat, cure or prevent any disease."

Researchers believe that the imbalance between cartilage erosion and regeneration in osteoarthritis suffers is caused by a lack of glycosaminoglycans. Glycosaminoglycans play a vital role in the structural integrity of cartilage. The compound appears to inhibit enzymes that deplete cartilage nutrition. Chondroitin sulfate molecules are long chains of sugars and sulfur that create tiny spaces filled with fluid. These spaces protect and cushion joints.


Immortal Antler Velvet Silver is a less potent form of antler velvet than the Gold. It’s the only all-natural 19:1 extract that contains a powerful blend of growth factors in a naturally occurring matrix, and the only all-natural proprietary matrix to deliver up to 45 mcg’s of IGF-1 per bottle, in addition to the full growth factor matrix. Delivering a full range of growth factors at a 19:1 ratio means it requires 19 lbs of velvet antler tips to create 1 lb of this complete formula. Immortal Antler Velvet Silver is extracted in organic grape alcohol and bottled in miron violet glass for maximum absorption and effectiveness.

First, the facts: Deer antler has been a popular element of Eastern medicine for centuries. And—like red meat, eggs, or milk—deer antler contains small amounts of insulin-like growth factor 1, or IGF-1, explains Oliver Catlin, president of the Banned Substances Control Group (BSCG), which tests dietary supplements for illegal performance enhancers.
Deer antler velvet can play a pivotal role in helping to not only relieve the symptoms of diseases that affect joints, such as osteoarthritis, they can possibly eliminate them entirely. The way it may do this is through the introduction of chondroitin sulfate and glucosamine sulfate into the body. Both of these compounds are abundant in deer antler velvet.
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