One study (duplicated in Medline) that used a water extract of Velvet Antler at 50-200mg/kg failed to inhibit the pain killing effect of Morphine yet reduced the rate at which rats became tolerant to Morphine over the course of 6 days when taken an hour prior to Morphine each day. Rats who were given Velvet Antler prior to Morphine also experienced 26.6-36.6% less withdrawal (dose-dependent) and reduced reverse tolerance and dopamine receptor supersensitivity relative to morphine control.
Published research has shown that IGF-1 can produce similar results to growth hormone. The catch? If you do the math from the study, a 150-pound man (that’s a pretty small guy, so a bigger man would need more) would have to take more than 25 million nanograms just to experience the growth hormone-like effects of more muscle, less fat, and faster recovery.
Aphrodisiac* - For a long time the alcohol extract has been used to strengthen reproductive organ function, but modern studies of deer antler velvet results are inconclusive concerning women and from men. Although some people do report benefit in intimacy, this may be because of the performance, blood circulation and stress adaptation effects.* So in other words, if your supplement doesn't have the alcohol extract in it don't expect the benefits of supplements made with it.*
A 2014 study published in Evidence Based Complimentary and Alternative Medicine tested whether or not deer antler extract would have an effect on fatigue in mice who were led to swim distances. The findings suggested that deer antler “might increase the muscle strength through the upregulation of genes responsible for muscle contraction and consequently exhibited the anti-fatigue effect in mice.” Deer antler seems to have a positive effect on genes involved in nine different signaling pathways that affect muscles, endurance and fatigue. These include GnRH signaling pathway and insulin signaling pathways, in addition to levels of troponins. (8) Deer antler may contribute to increases in muscle strength by increasing Tpm2 expression. This affects how muscles take up proteins and repair themselves. Other studies show some evidence that deer antler extract helps prevent muscle fatigue by activating the lactate dehydrogenase activities and reducing the levels of blood lactic acid and serum urea nitrogen.
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Tanejeva also tested the effect of deer antler velvet in athletes running three kilometer races. In the experiment, 50 men ran the distance and their completion time was recorded. Deer antler velvet extract was administered to half of the runners and the participants repeated the race. The group receiving the Pantocrin completed the subsequent race in a faster average time.
Currently, IGF-1 is banned by both the World Anti-Doping Agency and the Food and Drug Administration (FDA). However, deer antler spray seems to provide only very small amounts of IGF-1. This is why it’s no longer considered illegal. Insulin-like growth factor is also naturally found in other animal-derived foods, including eggs, milk and red meat. Some experts believe that the amount of IGF-1 obtained from using deer antler products is really not much more than from eating these foods.
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Velvet antler has been used in traditional Chinese medicine (TCM) that classifies many similar substances from a variety of species under the simplified Chinese name 鹿茸; (pinyin Lu Rong) and the commercial name Cervi Cornu Pantorichum. The two common species used within the TCM system are sika deer and red deer which are thought to be useful for treating yang deficiency syndromes.
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However, calcium and phosphorus levels (which are important for bone growth) did not differ among groups. Overall, the researchers concluded that “our results seem to support a role for dietary supplementation of EVA on growth and bone development in this model.” (9) However, it’s important to point out that this is a very high dose. It’s significantly above what most would take in supplement form.
All male members of the deer family, including elk, moose and reindeer (caribou), grow a new set of antlers each year’from scratch, in just a matter of months’then shed them at the end of the annual mating season. The ability to regenerate such large appendages each year is unique to this family among mammals and rare in the animal kingdom as a whole (horns, in contrast to antlers, are permanent and cannot be regrown). Understanding how it happens could have significant implications for human medicine, particularly in the fields of wound healing and organ regeneration.
In Asia, velvet antler is dried and sold as slices, or as a powder which may be boiled in water, usually with other herbs and ingredients, and consumed as a medicinal soup. In the traditional commercial trade of Korea and China, whole stick antler velvet is divided into three sections based upon their supposed properties. Although there is an absence of uniform standardization, these sections are known as the wax piece (uppers or tips), the blood piece (middles), and the bone piece (bottoms): the wax piece may be marketed as a growth tonic for children, the blood piece supposedly for joint and bone health, and the bone piece supposedly for calcium deficiency and geriatric needs. Early commercial activity in Russia between the 1930s and 1980s led to the production of an alcohol extract from deer antler velvet marketed under the Russian drug trade name Pantocrin (also pantocrine or pantokrin).
Deer antler velvet may help to increase macrophage activity. Macrophages are a type of white blood cell (immunity cell) that digests cellular debris, foreign substances, cancer cells, and other microorganisms. Macrophages help to stimulate defense mechanisms in the body by recruiting immune cells such as lymphocytes. With this increased number of white blood cells, your immunity system becomes strengthened and will have a better chance at fighting off a sickness or infection.
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