In rats undergoing left coronary artery ligation, those with heart failure were given either Velvet Antler (Deer) or Captopril as active control for 4 weeks with a third group given water. No significant changes in cardiac structure was noted with either Velvet Antlers or Captopril (with the heart tissue being enlarged after heart failure) although left ventricular ejection fraction (LVEF) and fractional shortening (LVFS) appeared to be improved in both treatment groups to approximately the same degree and the increase in serum Brain Natiuretic Peptide (BNP) that occurred with heart failure was attenuated the same degree in both interventions.
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