One study (duplicated in Medline) that used a water extract of Velvet Antler at 50-200mg/kg failed to inhibit the pain killing effect of Morphine yet reduced the rate at which rats became tolerant to Morphine over the course of 6 days when taken an hour prior to Morphine each day. Rats who were given Velvet Antler prior to Morphine also experienced 26.6-36.6% less withdrawal (dose-dependent) and reduced reverse tolerance and dopamine receptor supersensitivity relative to morphine control.
Chondroitin sulfate is a compound of connective tissues that are usually found in cartilage. Glucosamine sulfate is a natural building block for the growth and maintenance of healthy cartilage. Since osteoarthritis is caused by the deterioration of the cartilage in the bone joints, a daily supplement of deer antler velvet can help to stimulate the repair of deteriorated bone cartilage with healthy doses of chondroitin sulfate and glucosamine sulfate.
However, if you’ve never taken deer antler product before, chances are you’re considering trying it because you have a specific concern or problem and someone has suggested you try Deer Antler Velvet, or you saw something on the Internet and here you are. You’re wondering if this is the right product, or whether you should keep looking, right? So, here are the Top 10 Benefits of Deer Antler Velvet.
In 168 persons with stable Rheumatoid Arthritis but present pain (25-100mm on the VAS rating scale) given either 1g of Velvet Antler from Elk or placebo for 6 months noted that there were no significant differences between placebo and Velvet Antler in regards to pain. Another study by the same research group using a smaller sample (n=40) and graded doses of 430mg, 860mg, and 1290mg daily noted that there was a dose-dependent trend towards reduced pain symptoms but this was not statistically significant.
IGF-1 is currently on the World Anti-Doping Agency’s prohibited list due to how it gives athletes an unfair advantage in terms of building strength and muscle mass. (7) However, it’s still legal to use supplements that may provide IGF-1 or similar effects. Most of the studies that show positive results from using deer antler supplements have used high doses. And some have tested the product on animals (mice or rats) rather than humans.
Being a former collegiate athlete, I’m no stranger to working out. When a former teammate of mine started talking about this new, state of the art, health product and the effects he was getting from it, it peaked my interest needless to say. I remember him continually saying that I’d have to try it to believe what it does for you. Wow, I must now say that I know what he means (and then some)! First of all, this IGF-1 Plus™ Formula did have some impressive results for me in my workouts. It’s not only helped my strength, but it seems that I especially notice a difference in my joints and my recovery time. Since I lift with heavy weights, my joints used to ache after working out, but they no longer do! My endurance also has really improved as well. I’ve actually doubled the time and distance that I was doing before (and I’ve only been on it for a little over a month)! An unexpected (but much welcomed) improvement that has been incredible is in how clearly I’ve been able to think and I feel very little stress anymore. It almost like someone put a micro-computer chip in my brain that makes it work much more efficiently without trying nearly as hard. It’s one of those things that you have to try to really believe it (trust me, it has done much more than I expected it to). I look forward to turning a friend of mine on to it, since he’s a personal trainer and trains professional athletes! Thanks, Dr. Duarte. I plan to use your IGF-1 Plus™ from now on, and will stock up so I don’t run out!
On January 30, 2013, Vijay Singh professional PGA Tour golfer was caught unaware and openly admitted to the personal use of deer antler spray which contained a banned substance at the time. A week later the World Anti-Doping Agency (WADA) lifted the ban on deer antler spray, but with urgency, "Deer Antler Velvet Spray may contain IGF-1 and WADA recommends therefore that athletes be extremely vigilant with this supplement because it could lead to a positive test."  The consensus opinion of leading endocrinologists concerning any purported claims and benefits "is simply that there is far too little of the substance in even the purest forms of the spray to make any difference,"  and "there is no medically valid way to deliver IGF-1 orally or in a spray." 
A systemic review on human interventions makes note of a study conducted on patients of osteoarthritis (Edelman et al. 2000; cannot be located online) which found improvements in joint pain symptoms relative to baseline in the Velvet Antler group and not placebo, although a lack of information on blinding and randomization precludes results that can be drawn from this study.