1g of Velvet Antler taken daily for 12 weeks in otherwise healthy adult men has failed to significantly alter serum testosterone levels, either total or free testosterone. Another study in otherwise healthy men has also failed to find such an effect on the endocrine profile, with 11 weeks of 1.5g supplementation failing to alter serum testosterone and a lack of effects also noted after 10 weeks of 560mg in males and females who performed a consistent rowing regimen.
L-Arginine: An amino acid usually found in red meats that is important for the body’s ability to manufacture proteins. L-Arginine has been used to treat conditions like high blood pressure, congestive heart failure, blocked arteries, and erectile dysfunction. L-Arginine is safe for most people, however it should not be taken by women that are pregnant or breastfeeding.
An ethanolic extract has been noted to, following oral ingestion of 100mg/kg, suppress nitric oxide secretion from peritoneal macrophages while stimulating phagocytic activity secondary to calcium mobilization, and has been noted to increase macrophage cell count in a concentration dependent manner up to 171.5% at 150mcg/mL with a water extract (and 132.4% for splenocytes). This immunostimulation appears to be related to phosphatidylcholine molecules with saturated fatty acid acyl chains and is thought to underlie an anti-infective effect in mice infected with Staphylococcus aureus when Velvet Antler is ingested at 500mg/kg.
To determine the effects of deer antler velvet on maximal aerobic performance and the trainability of muscular strength and endurance, 38 active males were randomly assigned in a double-blind fashion to either deer antler velvet extract (n = 12), powder (n = 13), or placebo groups (n = 13). Subjects were tested prior to beginning supplementation and a 10-week strength program, and immediately post-training. All subjects were measured for circulating levels of testosterone, insulin-like growth factor, erythropoietin, red cell mass, plasma volume, and total blood volume. Additionally, muscular strength, endurance, and VO2max were determined. All groups improved 6 RM strength equivalently (41 +/- 26%, p < .001), but there was a greater increase in isokinetic knee extensor strength (30 +/- 21% vs. 13 +/- 15%, p = .04) and endurance (21 +/- 19% vs. 7 +/- 12%, p = .02) in the powder compared to placebo group. There were no endocrine, red cell mass or VO2max changes in any group. These findings do not support an erythropoetic or aerobic ergogenic effect of deer antler velvet. Further, the inconsistent findings regarding the effects of deer antler velvet powder supplementation on the development of strength suggests that further work is required to test the robustness of the observation that this supplement enhances the strength training response and to ensure this observation is not a type I error.
Deer antler Velvet Spray – the name is already quite intriguing. This may have caught the attention of those who’ve come across the spray. And when some of them saw that this covers joint care, then those who suffer from regular pains must have wanted to try it out. And like its name, the main component comes from powdered deer antlers. This may shock some consumers, but if you will visit the website, you’ll find that the manufacturers ensure that no animals are harmed.
The answer is that deer antler velvet is just another fat burner. Another cell volumizer. Another body-toning shoe. It’s fitness marketing at it’s finest—playing off a goal you desire (gaining more muscle and size) and drawing unsubstantiated and wildly exaggerated claims. There’s nothing miraculous about deer antler spray. And after a closer look at the product, there’s really—well—nothing to it at all.
First, the facts: Deer antler has been a popular element of Eastern medicine for centuries. And—like red meat, eggs, or milk—deer antler contains small amounts of insulin-like growth factor 1, or IGF-1, explains Oliver Catlin, president of the Banned Substances Control Group (BSCG), which tests dietary supplements for illegal performance enhancers.
On January 30, 2013, Vijay Singh professional PGA Tour golfer was caught unaware and openly admitted to the personal use of deer antler spray which contained a banned substance at the time. A week later the World Anti-Doping Agency (WADA) lifted the ban on deer antler spray, but with urgency, "Deer Antler Velvet Spray may contain IGF-1 and WADA recommends therefore that athletes be extremely vigilant with this supplement because it could lead to a positive test."  The consensus opinion of leading endocrinologists concerning any purported claims and benefits "is simply that there is far too little of the substance in even the purest forms of the spray to make any difference,"  and "there is no medically valid way to deliver IGF-1 orally or in a spray."