Insulin-like Growth Factor 1 (IGF-1) is an anabolic molecule which appears to induce growth of the antlers themselves, although testosterone may be the primary growth factor. Currently, there is no evidence that serum IGF-1 is increased following Velvet Antler ingestion with one study using 1.5g of Velvet Antler for 11 weeks failing to increase serum IGF-1.
Tonic Adaptogen* - This is a fancy concept that references the research into supplements that elicit a strengthening effect on the body and its systems.* They are tonic in action and stimulate clean holistic energy and prevent fatigue while helping us to overcome stress and maintain strong immune systems.* Due to some of the following actions we will see that this stress adaptation is generally physical in nature.
Deer antler velvet can act as a natural adaptogen, restoring homeostasis to an unbalanced body by helping where it is needed. Deer antler velvet has an effect on many systems of the body given its complex chemical composition. The active ingredients in deer antler velvet are mostly precursors that are required by the body to process substances that maintain its health and wellbeing.
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A systemic review on human interventions makes note of a study conducted on patients of osteoarthritis (Edelman et al. 2000; cannot be located online) which found improvements in joint pain symptoms relative to baseline in the Velvet Antler group and not placebo, although a lack of information on blinding and randomization precludes results that can be drawn from this study.