Insulin-like Growth Factor 1 (IGF-1) is an anabolic molecule which appears to induce growth of the antlers themselves,[31][32] although testosterone may be the primary growth factor.[33] Currently, there is no evidence that serum IGF-1 is increased following Velvet Antler ingestion with one study using 1.5g of Velvet Antler for 11 weeks failing to increase serum IGF-1.[26]
In a study on diabetic mice given topical wounds (scalpel and scissors to create a cricle; diabetes tends to reduce wound healing rates[34] and thus diabetic rats are a good research model for wound closure rates) where either a control cream or one containing 400mcg Velvet Antler (Elk; water soluble extract) noted that there was less angiogenesis and a trend towards less inflammation assocaited with Velvet Antler cream while on day 7 wounds treated with the Antler cream were significantly smaller than control.[35] One 3.2kDa protein has been noted to possess wound healing properties, which are dose-dependent and have been noted to improve wound healing induced by burns at 0.05-0.1% of solution[36] and in vitro at 10-40mcg/mL.[37]
Tonic Adaptogen* - This is a fancy concept that references the research into supplements that elicit a strengthening effect on the body and its systems.* They are tonic in action and stimulate clean holistic energy and prevent fatigue while helping us to overcome stress and maintain strong immune systems.* Due to some of the following actions we will see that this stress adaptation is generally physical in nature.
Deer antler velvet can act as a natural adaptogen, restoring homeostasis to an unbalanced body by helping where it is needed. Deer antler velvet has an effect on many systems of the body given its complex chemical composition. The active ingredients in deer antler velvet are mostly precursors that are required by the body to process substances that maintain its health and wellbeing.
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A systemic review on human interventions[25] makes note of a study conducted on patients of osteoarthritis (Edelman et al. 2000; cannot be located online) which found improvements in joint pain symptoms relative to baseline in the Velvet Antler group and not placebo, although a lack of information on blinding and randomization precludes results that can be drawn from this study.
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