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People with osteoarthritis take chondroitin sulphate as an anti-inflammatory and velvet antler contains a high concentration of this compound, as well as significant amounts of glucosamine sulphate. Both appear to inhibit the depletion of bone and cartilage. The use of velvet antler in treating rheumatoid arthritis is being studied at the University of Calgary and the University of Alberta.
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On January 30, 2013, Vijay Singh professional PGA Tour golfer was caught unaware and openly admitted to the personal use of deer antler spray which contained a banned substance at the time. A week later the World Anti-Doping Agency (WADA) lifted the ban on deer antler spray, but with urgency, "Deer Antler Velvet Spray may contain IGF-1 and WADA recommends therefore that athletes be extremely vigilant with this supplement because it could lead to a positive test."  The consensus opinion of leading endocrinologists concerning any purported claims and benefits "is simply that there is far too little of the substance in even the purest forms of the spray to make any difference,"  and "there is no medically valid way to deliver IGF-1 orally or in a spray." 
The truth? While research is limited, there’s nothing to suggest that deer antler velvet (or deer antler spray in the supplement form) actually does what it claims. In fact, there are two published studies (in real scientific journals, you can see them here and here) that suggest deer antler velvet does not (I repeat, does not) even elicit a hormonal response. What’s more, it also did not increase muscular strength or aerobic power.
Indeed, within weeks you may begin to notice less extra weight around the waist and a firmer belly (a.k.a. a smaller "spare-tire").* We tell them, "That is because your hormones are working better and why you are looking and feeling better from all that hard work exercising." We get a spare-tire because our body gets tired, Your new thing to do with your nutrition and fitness program will remove that spare-tire and replace it with a lean and solid waist that you and others can be proud of.
Deer Antler Velvet Extract: This moss-like substance has been used in Chinese medicine for years and is thought to contain a number of compounds that can help with tissue regeneration and repair. The antlers are removed safely and without harm to the animal, and the velvet is thought to have applications for improving circulation, strengthening bone density, and improving male libido. There is very little clinical data regarding the effects of deer velvet, and not much is known about its side effects. Some conditions that may potentially be related to deer antler velvet include:
As this supplement is derived from 'deer', the two most commonly used species of deer in mainland China include the Sika deer Cervus nippon Temminck and Red Deer Cervus elaphus Linnaeus; these species may be relevant. 'Farming' of deers for antlers includes raising deer and sawing off the antlers under analgesia, the annual yeild appears to be 120-150 tonnes and deer are not usually killed as antlers are capable of full regeneration.
Data is limited. Two studies (n=40 and 168) investigating the efficacy of elk velvet antler supplementation on rheumatoid arthritis found no effect, while a study conducted in people with osteoarthritis (n=53) reported symptomatic relief among participants. The small sample sizes may result in the trials being underpowered to detect effects.25, 28, 29
I took red mountain deer velvet and it really messed my stomach up. I now have cramps and bloating all the time plus it feels like my stomach shrank…I can’t eat like I used to. It was a big mistake to take that stuff. Do you know of any way I can get my stomach back to normal??? Can you recommend someone who knows a lot about deer velvet?? I have been suffering terribly since I took that junk…it’s been about 2 years now!!!! My stomach has never been the same since I took that poison!!