There must be a reason to is use and a booming world industry that garners the attention of several researchers and scientist in many countries. Modern understanding has greatly advanced our knowledge of velvet antler. We know by its composition and the knowledge of the structure and function of the plenitude of constituents which work together, like a symphony, to create an efficacious supplement that yields a multitude of benefits.
Deer antler velvet is rich in insulin-like growth factor 1 (IGF-1) which is a growth hormone produced naturally in the liver as a response to human growth hormone (HGH) stimulation. This is a key factor in how deer antler velvet can help to promote muscle growth. IGF-1 works on the body by promoting the growth of healthy, lean skeletal muscles. This growth of healthy muscle mass can be influenced by IGF-1's tendency to increase muscle protein and muscle DNA content. There is evidence to suggest that IGF-1 acts on muscle tissue by promoting protein synthesis and the proliferation of satellite cells, both of which result in skeletal muscle growth due to the enlargement of the muscle cells.
To be clear, some doctors and researchers have stated that they feel deer antler spray is unlikely to cause any significant benefits. This is because it only provides very small amounts of IGF-1, some of which may not even be fully absorbed. However, studies do show that higher doses, or using very high-quality supplements, may contribute to some improvements in performance, body composition, etc. IGF-1 itself has been studied extensively. It can certainly change the way the body looks and operates. Whether or not the role of IGF-1 in the body will translate into any real benefits when obtained from deer antler products will depend on the specific person and dosage used.
A systemic review on human interventions makes note of a study conducted on patients of osteoarthritis (Edelman et al. 2000; cannot be located online) which found improvements in joint pain symptoms relative to baseline in the Velvet Antler group and not placebo, although a lack of information on blinding and randomization precludes results that can be drawn from this study.