In Asia, velvet antler is dried and sold as slices, or as a powder which may be boiled in water, usually with other herbs and ingredients, and consumed as a medicinal soup. In the traditional commercial trade of Korea and China, whole stick antler velvet is divided into three sections based upon their supposed properties. Although there is an absence of uniform standardization, these sections are known as the wax piece (uppers or tips), the blood piece (middles), and the bone piece (bottoms): the wax piece may be marketed as a growth tonic for children, the blood piece supposedly for joint and bone health, and the bone piece supposedly for calcium deficiency and geriatric needs. Early commercial activity in Russia between the 1930s and 1980s led to the production of an alcohol extract from deer antler velvet marketed under the Russian drug trade name Pantocrin (also pantocrine or pantokrin).
Even more intriguing is how the stags manage to regrow their antlers. Scientists have found stem cells at the bases of antlers’essentially ‘blank’ cells that can develop into many different types of cell, such as a skin cell or a cartilage cell. If they could find out what triggers the stem cells and controls their development into antlers, the knowledge could be applied to the regeneration of human limbs and organs. Scientists know that the shedding is initiated by a fall in the hormone testosterone, a change linked to an increase in day length, and they think oestrogen may be a key cellular regulator. However, much more research on a molecular level is required to unravel what is clearly an intricate process.
One study published in the Journal of Ethnopharmacology found evidence that use of deer velvet antler may help strengthen joints and bones, reducing symptoms like joint pain associated with osteoarthritis. (10) After rats with osteoarthritic symptoms were given total velvet antler polypeptides from red deer (TVAPL) for 12 weeks, they showed signs of significant reversal in osteoporosis. The researchers found improvements in the rats’ bone weight coefficient (BWC), bone mineral density (BMD), and bone mineral content (BMC). They believe these effects were due to proliferation of cartilage and osteoblast-like cells, in addition to reductions in inflammation due to inhibition of interleukin-1 (IL-1).
One of the leading companies in the world that manufacturers deer antler spray is called Nutronics Labs. According to information posted on their website, they have been making deer antler supplements for two decades. They state that their deer antler products range in concentration/strength from about 25,000ng (nanograms)–200,000ng of IGF-1. According to studies done by Nutronics Labs, deer antler powders appear to be less concentrated with IGF-1. They also may be poorly absorbed compared to deer antler extract.
However, calcium and phosphorus levels (which are important for bone growth) did not differ among groups. Overall, the researchers concluded that “our results seem to support a role for dietary supplementation of EVA on growth and bone development in this model.” (9) However, it’s important to point out that this is a very high dose. It’s significantly above what most would take in supplement form.
Research has been conducted on the potential use of deer antler velvet for healing of wounds. In Russia (Arapov, 1969), Pantocrin was administered to patients with surgical and internal wounds. The study reported that there were a number of positive effects, including the normalization of arterial pressure, reduction in surgical complications, and becoming active quicker. In tests on rats (Wang, 1985), bone fracture repair was accelerated. A recent study by Bubenik found that antler helped heal epidermal wounds in rats. In another study by Takikawa, et al., researchers reported observing new bone formation following experimental whiplash injuries in rabbits. Pretreatment in rats reduced cell degradation and improved recovery times from extreme temperature and electric shock exposure.
The FDA considers deer antler spray (or deer antler velvet) to be a dietary supplement. This means it doesn’t need to be extensively studied and regulated like medications. For this reason, it can be hard to tell what the actual concentration of active ingredients or IGF-1 is in various supplements. Plus products can differ quite a bit from one brand to another in terms of their purity and effectiveness.
As this supplement is derived from 'deer', the two most commonly used species of deer in mainland China include the Sika deer Cervus nippon Temminck and Red Deer Cervus elaphus Linnaeus; these species may be relevant. 'Farming' of deers for antlers includes raising deer and sawing off the antlers under analgesia, the annual yeild appears to be 120-150 tonnes and deer are not usually killed as antlers are capable of full regeneration.
Shake bottle before each use. Take 14 drops under the tongue 3 times per day. Hold for 20 seconds before swallowing for best results. This allows the formula to penetrate through your endocrine glands. Then the active molecules are then released directly into your bloodstream. This is how Nutronics Labs' liposome technology is able to deliver an enhanced bioavailability!