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Even more intriguing is how the stags manage to regrow their antlers. Scientists have found stem cells at the bases of antlers’essentially ‘blank’ cells that can develop into many different types of cell, such as a skin cell or a cartilage cell. If they could find out what triggers the stem cells and controls their development into antlers, the knowledge could be applied to the regeneration of human limbs and organs. Scientists know that the shedding is initiated by a fall in the hormone testosterone, a change linked to an increase in day length, and they think oestrogen may be a key cellular regulator. However, much more research on a molecular level is required to unravel what is clearly an intricate process.
1g of Velvet Antler taken daily for 12 weeks in otherwise healthy adult men has failed to significantly alter serum testosterone levels, either total or free testosterone.[8] Another study in otherwise healthy men has also failed to find such an effect on the endocrine profile, with 11 weeks of 1.5g supplementation failing to alter serum testosterone[26] and a lack of effects also noted after 10 weeks of 560mg in males and females who performed a consistent rowing regimen.[28]
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One study[14] (duplicated in Medline[15]) that used a water extract of Velvet Antler at 50-200mg/kg failed to inhibit the pain killing effect of Morphine yet reduced the rate at which rats became tolerant to Morphine over the course of 6 days when taken an hour prior to Morphine each day.[14] Rats who were given Velvet Antler prior to Morphine also experienced 26.6-36.6% less withdrawal (dose-dependent) and reduced reverse tolerance and dopamine receptor supersensitivity relative to morphine control.[14]
For a long time velvet antler is recognized as a powerful tonic that naturally stimulates us with a clean and non-fatiguing energy. Not like coffee or energy drinks. This effect can be subtle, but its long term consumption benefits are profound in that we can more easily overcome and adapt to daily stress. Many types of stress depending on who we are as individuals. How much to take is important and talked about in the dosage section. Having the capability of increased resistance to physical stress is a major use to everyone. 
In 168 persons with stable Rheumatoid Arthritis but present pain (25-100mm on the VAS rating scale) given either 1g of Velvet Antler from Elk or placebo for 6 months noted that there were no significant differences between placebo and Velvet Antler in regards to pain.[23] Another study by the same research group using a smaller sample (n=40) and graded doses of 430mg, 860mg, and 1290mg daily noted that there was a dose-dependent trend towards reduced pain symptoms but this was not statistically significant.[24]
Deer antler velvet is the tissue that covers the bone and cartilage that develop into deer (and elk) antlers. It has been harvested for centuries and used traditionally to increase strength, boost the immune system, and counter the effects of stress. Now it’s promoted to improve athletic performance; raise testosterone levels to increase sex drive, fertility and erectile function in men; as well as to reduce the signs of aging and treat problems ranging from high cholesterol, high blood pressure, asthma and osteoporosis to migraine headaches, indigestion, and many more.
A systemic review on human interventions[25] makes note of a study conducted on patients of osteoarthritis (Edelman et al. 2000; cannot be located online) which found improvements in joint pain symptoms relative to baseline in the Velvet Antler group and not placebo, although a lack of information on blinding and randomization precludes results that can be drawn from this study.
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