Velvet Antler is a supplement derived from powdered or crushed antlers, most commonly from deer (and thus referred to as Deer Velvet Antler) although Elk have also been used. They have been used in Traditional Chinese Medicine. The base of the antler is referred to as Cervus (in reference to deers), Lu Jiao Pan, Zhen Zhu Pan, as well as Lu Hua Pan and appears to have been traditionally used for cardiovascular disease, gynecological problems, immunological deficiencies, blood cancers, tissue repair and health promotion. The specific part used is the antler base; when the antler is sawed off the base temporarily remains until the regeneration of the new antler pushes it off which occurrs occasionally in the wild. Traditional usage involves using the base and macerating it in wine or decocting it with water for oral consumption.
IGF-1 is currently on the World Anti-Doping Agency’s prohibited list due to how it gives athletes an unfair advantage in terms of building strength and muscle mass. (7) However, it’s still legal to use supplements that may provide IGF-1 or similar effects. Most of the studies that show positive results from using deer antler supplements have used high doses. And some have tested the product on animals (mice or rats) rather than humans.
On January 30, 2013, Vijay Singh professional PGA Tour golfer was caught unaware and openly admitted to the personal use of deer antler spray which contained a banned substance at the time. A week later the World Anti-Doping Agency (WADA) lifted the ban on deer antler spray, but with urgency, "Deer Antler Velvet Spray may contain IGF-1 and WADA recommends therefore that athletes be extremely vigilant with this supplement because it could lead to a positive test."  The consensus opinion of leading endocrinologists concerning any purported claims and benefits "is simply that there is far too little of the substance in even the purest forms of the spray to make any difference,"  and "there is no medically valid way to deliver IGF-1 orally or in a spray." 
To be clear, some doctors and researchers have stated that they feel deer antler spray is unlikely to cause any significant benefits. This is because it only provides very small amounts of IGF-1, some of which may not even be fully absorbed. However, studies do show that higher doses, or using very high-quality supplements, may contribute to some improvements in performance, body composition, etc. IGF-1 itself has been studied extensively. It can certainly change the way the body looks and operates. Whether or not the role of IGF-1 in the body will translate into any real benefits when obtained from deer antler products will depend on the specific person and dosage used.
The IGF-1 found in deer antler spray is derived from deer antler velvet, the tissue found inside the deer's antlers before they fully harden. Since deer antlers grow incredibly fast, it is not surprising that the horns are rich in IGF-1. This is a naturally-occurring form of IGF-1, meaning it is not made in a lab. As a result, deer antler velvet is considered a dietary supplement by the Food and Drug Administration, and unlike synthesized drugs, the product does have to be proven safe or effective before it's sold to the public.
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Russian and Japanese researchers have conducted experiments using deer antler extract and found that it appears to lower blood pressure in both human subjects and laboratory animals. A series of clinical case studies (Albov, 1969) were conducted in which the effects of Pantocrin on cardiac patients were assessed. In one test involving 32 subjects with high blood pressure caused by cardiac disease, early onset menopause or obesity, blood pressure was lowered in 81% of patients. In another study involving 13 patients with hypotension caused by disorders of heart muscle activity, blood pressure was lowered for 84% of patients.
One of the leading companies in the world that manufacturers deer antler spray is called Nutronics Labs. According to information posted on their website, they have been making deer antler supplements for two decades. They state that their deer antler products range in concentration/strength from about 25,000ng (nanograms)–200,000ng of IGF-1. According to studies done by Nutronics Labs, deer antler powders appear to be less concentrated with IGF-1. They also may be poorly absorbed compared to deer antler extract.
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