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Using deer antler velvet benefits sexual functions and libido by helping to increase gonadotropin hormones which include luteinizing hormone (LH) and follicle-stimulating hormone (FSH). Luteinizing hormone (LH) and follicle-stimulating hormone are hormones that stimulate the sex glands. The stimulation of the sex glands is pivotal for sexual reproduction. Without the presence of the gonadotropin hormones, the sexual organs will fail at their purpose and the individual will be considered infertile. As the deer antler velvet promotes an increase in LH, the LH causes the testes to produce more testosterone.
S.W.A.T.S. Fitness and Performance was a dietary supplement company that sold deer antler spray and other products. The owners began distributing their products to NCAA and NFL athletes in 2008. The controversy initially started in March 30, 2009 when Alabama athletic officials sent a cease-and-desist letter to the company's owner that stated: "Refrain from using current student-athletes to endorse products. Refrain from contacting current student-athletes. Refrain from giving or selling products to current student-athletes."  The letter was then sent again in 2012.
There is some evidence that deer antler spray may work for improving performance and physique. However, it seems that an individual needs to take very high doses in order for these benefits to occur. In studies where the supplement was effective, injections of very concentrated extracts were used. Injections may be the most effective, and likely the only, way that deer antler works. This is because IGF-1 is mostly destroyed when it passes through the digestive system. Because of this, swallowing deer antler supplements would practically be useless.
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Deer antler velvet can act as a natural adaptogen, restoring homeostasis to an unbalanced body by helping where it is needed. Deer antler velvet has an effect on many systems of the body given its complex chemical composition. The active ingredients in deer antler velvet are mostly precursors that are required by the body to process substances that maintain its health and wellbeing.
In a randomized, placebo controlled test in 2004, researchers at the University of Alberta, Canada, placed 18 males from the Edmonton Police Force into a 9 week strength training program. The results showed that deer antler velvet increased the strength and endurance of the subjects relative to the control group. The researchers found that use of deer antler velvet significantly increased blood plasma testosterone levels.