After about 55-60 days of growth the velvet antler is removed painlessly from the deer in less than 60 seconds so that it may be done as humanely as possible. These deer are not harmed and experience no pain in the removal of their velvet antlers for our consumption. The antler is then scraped of its fuzzy velvet and then cleaned before it is sanitized and pasteurized for safety, and then inspected for quality grading.
A systemic review on human interventions makes note of a study conducted on patients of osteoarthritis (Edelman et al. 2000; cannot be located online) which found improvements in joint pain symptoms relative to baseline in the Velvet Antler group and not placebo, although a lack of information on blinding and randomization precludes results that can be drawn from this study.
The appropriate dose of deer velvet depends on several factors such as the user's age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of doses for deer velvet. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.
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Velvet antler in the form of deer antler spray has been at the center of multiple controversies with professional sports leagues and famous athletes allegedly using it for injury recovery and performance enhancement purposes. In mid-2011 a National Football League (NFL) player successfully sued a deer antler velvet spray manufacturer for testing positive for methyltestosterone in 2009 for a total amount of 5.4 million US dollars. In August 2011, Major League Baseball (MLB) added deer antler spray to their list of prohibited items because it contains "potentially contaminated nutritional supplements." 
Although the site states that this product shouldn’t cause ill side effects, most western medical practitioners would dissuade you from taking this because the components found in deer antlers haven’t been approved by the FDA. More importantly, IGF-1 has been proven unstable. So, it’s best to speak to your physician, especially when you’re currently taking other forms of medication.
A study by Chen found that deer antler velvet inhibits monoamine oxidase activity in the liver and brain tissues of aged mice. Monoamine-oxidase inhibitors prevent breakdown of monoamine neurotransmitters such as norepinephrine and serotonin. Antler apparently allows these vital neurotransmitters to be available longer to the brain structure, enhancing mood.
Disclaimer: The information provided within this site is strictly for the purposes of information only and is not a replacement or substitute for professional advice, doctors visit or treatment. The provided content on this site should serve, at most, as a companion to a professional consult. It should under no circumstance replace the advice of your primary care provider. You should always consult your primary care physician prior to starting any new fitness, nutrition or weight loss regime.
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If you have any existing medical condition that requires taking medication, always consult your physician before taking any new products. Discuss if deer antler spray will be safe for you to use if you have a history of serious hormonal problems, heart disease, liver or kidney disease, or any other serious condition. It’s also not wise to stop taking any medications you’ve been taking or to end physical therapy sessions/exercises because you’ve started taking deer antler spray. Always follow up with your doctor or therapist if you have questions about changing your recovery plan regarding an injury or illness.
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A 2014 study published in Evidence Based Complimentary and Alternative Medicine tested whether or not deer antler extract would have an effect on fatigue in mice who were led to swim distances. The findings suggested that deer antler “might increase the muscle strength through the upregulation of genes responsible for muscle contraction and consequently exhibited the anti-fatigue effect in mice.” Deer antler seems to have a positive effect on genes involved in nine different signaling pathways that affect muscles, endurance and fatigue. These include GnRH signaling pathway and insulin signaling pathways, in addition to levels of troponins. (8) Deer antler may contribute to increases in muscle strength by increasing Tpm2 expression. This affects how muscles take up proteins and repair themselves. Other studies show some evidence that deer antler extract helps prevent muscle fatigue by activating the lactate dehydrogenase activities and reducing the levels of blood lactic acid and serum urea nitrogen.
There is an increasing amount of scientific evidence supporting the benefits of deer antler velvet from decades of research carried out in Russia, Korea, China, Japan, Australia and New Zealand. This research has given credibility to deer antler velvet’s traditional usage and validated recommendations for its inclusion as an everyday health supplement. Almost 250 papers have been published since 1930 on the manufacture, composition and biochemical effect of deer antler velvet. Studies on deer antler velvet and the corresponding findings are described below.